Preparation of PLLAMPEG Microbrushes for Resistance of Protein Adsorption

Poly(Llactic acid)copoly(ethylene glycol)(PLLAMPEG) microbrushes were prepared by LB technique, casting and chemical grafting onto PLLA films. The effects of preparing conditions on the properties of microbrush layers were studied by atomic force microscope (AFM) and water contact angle. The stability, hydrophilicity and protein resistance ability of these microbrush layers were also thoroughly studied and compared. Results show that PLLAMPEG microbrush layers prepared by the three methods are all hydrophilic and show resistance of protein adsorption. PLLAMPEG LB film is dealt with hot water to increase its stability. The casting PLLAMPEG layer has a good filming property but the stability is bad. The microbrushes prepared by photocatalysis method could bind firmly on PLLA casting film, which is possible to be used in surface modification of medical devices and implanting materials.