Synthesis and Antitumor Activit of Polyphosphoramides and Polyphosphates Containning Amino Acid,5-Flcorouracil and Phosphonoformate or Phosphonoacetate
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Graphical Abstract
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Abstract
Twenty new polyphosphoramides and polyphosphates were peepared from aminoacid 5--fluorouracil--1, 3--dipropylesters with (ethoxyacetyl) phosphonic dichloride or(ethoxycarbonyl) phosphonic dichloride in DMF in vacuo or in the presence of Et_3N.The polymers
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