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    LUAN Ke, BAN Yu, SHI Dean, SHI Hengchong. Construction Strategy and Research Progress of Anticoagulant Surface of Medical Polymeric Materials[J]. Journal of Functional Polymers, 2021, 34(2): 172-181. doi: 10.14133/j.cnki.1008-9357.20201226001
    Citation: LUAN Ke, BAN Yu, SHI Dean, SHI Hengchong. Construction Strategy and Research Progress of Anticoagulant Surface of Medical Polymeric Materials[J]. Journal of Functional Polymers, 2021, 34(2): 172-181. doi: 10.14133/j.cnki.1008-9357.20201226001

    Construction Strategy and Research Progress of Anticoagulant Surface of Medical Polymeric Materials

    • Biomedical polymer materials and medical devices are mainly used for the diagnosis and treatment of diseases, and are used by thousands of patients every day. When this material/device is implanted/intervened in the human body and comes into contact with blood, plasma proteins will adsorb to the surface of the material/device within a few seconds and bind to the glycoprotein receptor on the platelet, resulting in platelet activation, coagulation cascade and complement activation, coagulation and thrombus. Human health and life safety are seriously endangered. To impart anticoagulant properties to the surface of materials/devices, it is necessary to construct anticoagulant surfaces in a targeted manner. The main methods are as follows: biologically inert coatings, biologically active coatings, surface coatings with endothelial (EC) specific growth factors, and composite anti-coagulation coating. Based on the research developments in this field at home and abroad and the research results of our group in recent years in the construction of anticoagulant surface of biomedical polymer material and medical device, this review summarizes the research progress of anticoagulant surface construction and its application in medical devices.
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