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    张克娜, 周家华, 杜德焰, 倪忠斌, 陈明清, 施冬健. 亲水-疏水双网络水凝胶的制备及其黏合性能[J]. 功能高分子学报,2023,36(2):126-135. doi: 10.14133/j.cnki.1008-9357.20221225001
    引用本文: 张克娜, 周家华, 杜德焰, 倪忠斌, 陈明清, 施冬健. 亲水-疏水双网络水凝胶的制备及其黏合性能[J]. 功能高分子学报,2023,36(2):126-135. doi: 10.14133/j.cnki.1008-9357.20221225001
    ZHANG Kena, ZHOU Jiahua, DU Deyan, NI Zhongbin, CHEN Mingqing, SHI Dongjian. Preparation and Adhesion Properties of Bio-Hydrogels with Hydrophilic-Hydrophobic Double Networks[J]. Journal of Functional Polymers, 2023, 36(2): 126-135. doi: 10.14133/j.cnki.1008-9357.20221225001
    Citation: ZHANG Kena, ZHOU Jiahua, DU Deyan, NI Zhongbin, CHEN Mingqing, SHI Dongjian. Preparation and Adhesion Properties of Bio-Hydrogels with Hydrophilic-Hydrophobic Double Networks[J]. Journal of Functional Polymers, 2023, 36(2): 126-135. doi: 10.14133/j.cnki.1008-9357.20221225001

    亲水-疏水双网络水凝胶的制备及其黏合性能

    Preparation and Adhesion Properties of Bio-Hydrogels with Hydrophilic-Hydrophobic Double Networks

    • 摘要: 选用N-丙烯酰基甘氨酸(ACG)与N-丙烯酰基-L-苯丙氨酸(ACP)为单体,通过自由基共聚,制备由氢键和化学交联双网络构筑的P(ACGx-ACPy)水凝胶。通过调节ACG和ACP的组分比,对聚合物分子间作用力与凝胶的综合性能进行调控。分别利用搭接剪切和拉伸测试方法对水凝胶的黏合性能进行测试。结果显示:当水凝胶中n(ACG)∶n(ACP)=1∶1时,其黏合性能最好,对猪皮的最大湿黏合强度可达到80.2 kPa;同时,水凝胶的最高压缩强度最高可达2.2 MPa;细胞毒性试验显示水凝胶的生物相容性良好。

       

      Abstract: Wet (underwater) adhesive materials have wide applications in biomedical and engineering fields. However, a hydration layer on the substrate surface severely prevents the interface interaction between adhesives and substrates, resulting in sharp reduce or even disappearance of the wet adhesion property. Therefore, it is of great significance to prepare adhesive materials with wet adhesion property by removal of the hydration layer via hydrophobic interaction. In this paper, amino acid based monomers, N-acrylylglycine (ACG) and N-acrylyl-L-phenylalanine (ACP) were synthesized, and then poly(N-acrylylglycine-N-acrylyl-L-phenylalanine) hydrogels (P(ACGx-ACPy)) were further prepared via hydrogen cross-linking and chemical cross-linking. The intermolecular interactions and properties of the P(ACGx-ACPy) hydrogels were regulated by adjusting the composition ratio of ACG to ACP. Their adhesive properties were then detected by lap-shear and tensile tests, respectively. The results showed that the hydrogels had well adhesive properties. The maximum wet lap-shear adhesive strength to pig skin could reach 80.2 kPa, when the molar ratio of ACG to ACP of hydrogel was 1∶1. Moreover, the highest compression strength of the hydrogels was 2.2 MPa. Cytotoxicity tests showed that hydrogels had good biocompatibility. The prepared P(ACGx-ACPy) adhesives has the potential applications to bio-tissue and other wet materials repairing.

       

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