抗菌阳离子聚合物的研究进展

朱欣怡; 丁圣刚; 聂旋; 尤业字

doi:10.14133/j.cnki.1008-9357.20221128001

抗菌阳离子聚合物的研究进展

doi: 10.14133/j.cnki.1008-9357.20221128001

朱欣怡^1,,
丁圣刚²,
聂旋^1, ,,
尤业字^1,

1.
中国科学技术大学高分子科学与工程系，中国科学院软物质化学重点实验室，合肥 230026
2.
安徽医科大学第一附属医院, 合肥 230022

基金项目: 国家自然科学基金（U22A20154, 52273113）

详细信息

作者简介:
朱欣怡（2000—），女，硕士生，主要研究方向为生物材料。E-mail：zxy00 zxy@mail.ustc.edu.cn

聂旋，中国科学技术大学化学与材料科学学院博士后。2016年本科毕业于浙江工业大学，2021年获得中国科学技术大学博士学位（导师为尤业字教授）并从事博士后研究工作。目前主要研究方向为功能性生物材料及纳米药物的构建及应用，尤其是生物可降解的核酸递送材料、肿瘤微环境响应的智能材料、新型抗菌聚合物设计等领域，在Chemical Engineering Journal、ACS Applied Materials & Interfaces等期刊发表学术论文10余篇

尤业字，中国科学技术大学化学与材料科学学院、中科院软物质化学重点实验室教授，博士生导师。2008年加入中国科学技术大学，2011年获得教育部新世纪优秀人才，2016年获得国家自然科学基金委杰出青年科学基金资助。多年来一直从事可控聚合与功能性生物材料设计与构筑研究工作，主持或参与多个科技部重点研发、基金委重点项目、基金委创新团队、联合创新基金与面上项目等基金。目前主要研究方向为高分子的精准合成、高分子智能药物与核酸蛋白质输送，在Nature Metabolism、Nature Communications、Advanced Materials、Angewandte Chemie、Journal of the American Chemical Society等期刊发表学术论文150多篇

通讯作者:
聂　旋， E-mail：niexuan@ustc.edu.cn

尤业字，E-mail：yzyou@ustc.edu.cn

中图分类号: O63
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- PDF下载量: 44
- 被引次数: 0
出版历程
- 收稿日期: 2022-11-28
- 录用日期: 2023-01-13
- 网络出版日期: 2023-01-18

Progress of Antibacterial Polycation

ZHU Xinyi^1
,,
DING Shenggang²,
NIE Xuan^{1
, ,},
YOU Yezi^1
,

1.
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China
2.
The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

摘要

摘要: 两亲性阳离子聚合物在抗细菌感染，尤其是抵抗细菌耐药、突破细菌生物膜障碍中发挥着重要作用。为了进一步增加阳离子聚合物与细菌等病原体的相互作用，在提高杀菌效率的同时提高生物相容性，研究者们设计与制备了一系列具有优良性能的阳离子聚合物。本文综述了近年来新型阳离子聚合物的设计、制备及其在抗病原体方面的应用，讨论了不同阳离子聚合物的作用机理与特点，并对该领域所面临的挑战进行了展望。
- 阳离子聚合物 /
- 耐药 /
- 生物膜 /
- 抗菌材料 /
- 抗菌机理
Abstract: Polycation exhibit great potential application in the fields of anti-infection, especially in combating drug-resistant bacteria and breaking through the barrier of biofilm. To enhance the interaction between the prepared polymers and bacteria and the bacterial killing efficacy, a series of biocompatible polycations with excellent performance have been designed and constructed. In this review, the recent progresses in design, preparation, and the application of functional cationic antimicrobial polymers are summarized, and the antimalarial mechanism and the unique properties are discussed. Finally, the current challenges and future perspectives in cationic antimicrobial polymers are put forward.
- polycation /
- drug-resistance /
- biofilm /
- anti-bacterial material /
- antibacterial mechanism

HTML全文

图 1 常见阳离子抗菌聚合物的结构

Figure 1. Structures of common cationic antibacterial polymers

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图 2 (a) 酸响应嵌段共聚物选择性杀菌^[45]；(b) 多肽聚合物用于水产抗感染治疗^[46]；(c) 聚赖氨酸衍生物用于真菌感染治疗^[51]；(d) 基于噁唑啉的仿肽聚合物用于抵抗细菌耐药^[52]

Figure 2. (a) Selective bacterial killing with acid-responsive block copolymer^[45]; (b) Peptide polymer for anti-infection treatment of aquatic products^[46]; (c) Polylysine derivatives for treatment of fungal infections^[51]; (d) Poly(2-oxazoline) based functional mimics of peptides to combat the drug-resistant^[52]

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图 3 (a) 生物可降解聚碳酸酯用于细菌膜选择性溶解^[53]；(b) 通过取代基调节高分子链疏水性实现高选择性杀菌^[54]；(c) 环状阳离子聚合物的构建及高效抗菌^[58]

Figure 3. (a) Biodegradable polycarbonate for selective dissolution of bacterial membrane^[53]; (b) High selectivity bacterial with different hydrophobic substitutes group^[54]; (c) Construction of cyclic cationic polymers and application in bacterial killing^[58]

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图 4 (a) 胍基盐修饰的柱芳烃用于高效抑制细菌生物膜^[69]；(b) 含有胍基侧基的聚碳酸酯实现无耐药杀菌^[70]；(c) 含有胍基侧基的噁唑啉用于抗真菌感染治疗^[71]

Figure 4. (a) Guanidine modified column pillararene for efficient inhibition of bacterial biofilm^[69]; (b) Polycarbonate with guanidine side group kills the bacterial without drug resistant^[70]; (c) Guanidinium-functionalized poly (2-oxazoline) s combat the fungal infections^[71]

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图 5 (a) 类肽鋶鎓聚合物的构建及在抗细菌感染治疗中的应用^[75] ；(b) 环氧开环反应制备鋶鎓聚合物用于选择性杀菌^[77]；(c) 利用巯基-烯点击反应制备鋶鎓聚合物用于抗生物膜^[78]

Figure 5. (a) The construction of polysulfoniums-based functional mimics of peptides in bacterial killing^[75]; (b) Polysulfoniums through the reaction of epoxy ring opening for selective bacterial killing^[77]; (c) Polysulfoniums through thiol-ene click reaction for anti-biofilm^[78]

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图 6 (a) 阳离子聚合物联合光热效应用于抗细菌感染治疗^[83]；(b) 含有季膦盐的蛋白质水凝胶在伤口修复上的应用^[84]；(c) 季膦盐改性的超渗透抗菌聚酰胺复合膜^[86]

Figure 6. (a) Cationic polymer combined with photothermal therapy for treatment of bacterial infection^[83]; (b) Phosphonium-containing protein hydrogel for wound dressing^[84]; (c) Phosphonium modification improves the antibacterial and permeation activity of polyamide composite membranes^[86]

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图 7 (a) 二茂钴阳离子聚合物降低β-内酰胺药物耐药性^[103]；(b) 可回收的金属-抗生素偶联用于抗细菌感染治疗^[104]；(c) 基于钴离子配位抗菌表面的构建及抗菌应用^[106]

Figure 7. (a) Metallopolymers decrease the drug-resistant of β-Lactam^[103]; (b) recyclable magnetic nanoparticles grafted with antimicrobial metallopolymer-antibiotic bioconjugates for antibacterial therapy^[104]; (c) The construction of antibacterial surface based on cobalt ion^[106]

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图 8 含锌阳离子聚合物的（a）合成及（b）细胞壁合成抑制^[107]

Figure 8. (a) Synthesis of zinc containing cationic polymers and (b) inhibition of cell wall synthesis^[107]

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