Abstract: Reversible deactivation radical polymerization (RDRP) is one of the most widely used methods in the field of polymer synthesis. It can achieve precise control of molecular weight, molecular weight distribution and polymer structure, greatly promoting the synthesis and development of functional polymer materials. Compared with traditional flask and tank reactors, the flow reactor has the advantages of large specific surface area, high mass and heat transfer efficiency, etc., which can not only effectively accelerate the reaction rate of RDRP and reduce the occurrence of side reactions, but also provides uniform and sufficient light for photo-controlled reversible deactivation radical polymerization (photo-RDRP). In addition, with the rapid development of computer science, computer-aided flow polymerization has become one of the cutting-edge technologies for polymer synthesis. This review gives an overview of the development of thermal and photo-initiated RDRP in flow chemistry at first, and then introduces the latest research progress in flow polymerization from three aspects: precise synthesis, high-throughput synthesis and self-optimized synthesis. Finally, a brief summary and prospect of the flow polymerization are given.