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    曾贝迪, 陈 涛, 赵黎明. 聚丁内酰胺/壳聚糖电纺纳米蛛网复合纤维膜的制备及性能[J]. 功能高分子学报,2022,35(3):244-251. doi: 10.14133/j.cnki.1008-9357.20210603001
    引用本文: 曾贝迪, 陈 涛, 赵黎明. 聚丁内酰胺/壳聚糖电纺纳米蛛网复合纤维膜的制备及性能[J]. 功能高分子学报,2022,35(3):244-251. doi: 10.14133/j.cnki.1008-9357.20210603001
    ZENG Beidi, CHEN Tao, ZHAO Liming. Preparation and Properties of Polybutyrolactam/Chitosan Electrospun Composite Fiber Membranes with Nano-Cobweb Structure[J]. Journal of Functional Polymers, 2022, 35(3): 244-251. doi: 10.14133/j.cnki.1008-9357.20210603001
    Citation: ZENG Beidi, CHEN Tao, ZHAO Liming. Preparation and Properties of Polybutyrolactam/Chitosan Electrospun Composite Fiber Membranes with Nano-Cobweb Structure[J]. Journal of Functional Polymers, 2022, 35(3): 244-251. doi: 10.14133/j.cnki.1008-9357.20210603001

    聚丁内酰胺/壳聚糖电纺纳米蛛网复合纤维膜的制备及性能

    Preparation and Properties of Polybutyrolactam/Chitosan Electrospun Composite Fiber Membranes with Nano-Cobweb Structure

    • 摘要: 以生物基材料聚丁内酰胺(PBL)和壳聚糖(CS)为原料,考察了PBL/CS的混合液比例以及混合液浓度对纺丝混合液性质及电纺纤维膜的影响,并探讨了所制得电纺复合纤维膜的细胞相容性。结果表明:增加共混物中CS的含量及混合液浓度均会引起纺丝混合液电导率及黏度的增加;当混合液电导率的增加幅度较大时,有利于制得具有纳米蛛网结构的纤维膜;CS的加入抑制了PBL的结晶,制得的纤维结晶度低,甚至为无定形态。3-(4,5-二甲基噻唑-2)-2,5-二苯基四氮唑溴盐(MTT)实验表明:PBL/CS纤维膜无细胞毒性,可促进细胞增殖,且具有纳米蛛网结构的电纺复合纤维膜的细胞增殖效果更佳。

       

      Abstract: Nano-cobweb fibers supported by conventional electrospun fibers are 2D membranes with structure similar to spider webs, for which the average diameter is less than 50 nm and can be potentially applied in the fields of fine filter, sensor, tissue engineering, high performance protective clothing etc. Herein, polybutyrolactamide (PBL) and chitosan (CS), both derived from biomass and are biodegradable, were applied to construct the electrospun composite fiber membranes with nano-cobweb structure. The effects of blending ratio of PBL to CS and the solution concentration on solution properties as well as the fiber morphology and membrane structure were investigated. The cell compatibility of the electrospun composite fiber membranes was also discussed. It is found that the addition of polycationic CS improved the spinnability of PBL/FA solutions and the composite fibers could be continually electrospun. As the CS mass fractiong was increased, the conductivity and viscosity of the solutions both increased. Varying CS mass fraction in PBL/CS blend from 10% to 30% at fixed solution mass fraction of 8.0%, the solution viscosity increased even more than the conductivity did, and only fiber membranes without nano- cobweb structure were obtained. Increasing solution concentration also increased the solution conductivity and viscosity, but the increase in conductivity was more significant, which proved to be beneficial to electrospinning composite fiber membranes with nano-cobweb structure. When CS mass fraction in PBL/CS blend was 10%, increasing solution mass fraction from 8.0% to 9.0% didn’t help to get nano-cobweb structure. The nano-cobweb structure with breakages was obtained when CS mass fraction was 20% at the solution mass fraction of 10.0%. The composite fiber membranes with perfect nano-cobweb structure and 100% coverage could be electrospun by further increasing CS mass fraction and solution mass fraction to 30% and 11.0%, respectively. The results of Fourier transform infrared (FT-IR) spectroscopy and X-ray diffraction (XRD) indicated that the addition of CS inhibited the crystallization of PBL and the composite fibers of low crystallinity and even amorphous. The results of 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay confirmed that PBL/CS electrospun composite fiber membranes were noncytotoxic and could promote cell proliferation, especially for those with nano-cobweb structures. Such biobased and biodegradable composite fiber membranes are promising materials in the field of wound-dressing, nerve repairing and regenerative tissue engineering.

       

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