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    范瑶, 梁文城, 王友长, 郎美东. 聚乙烯醇/ε-聚赖氨酸水凝胶伤口敷料的制备及性能[J]. 功能高分子学报, 2022, 35(1): 85-92. doi: 10.14133/j.cnki.1008-9357.20210330002
    引用本文: 范瑶, 梁文城, 王友长, 郎美东. 聚乙烯醇/ε-聚赖氨酸水凝胶伤口敷料的制备及性能[J]. 功能高分子学报, 2022, 35(1): 85-92. doi: 10.14133/j.cnki.1008-9357.20210330002
    FAN Yao, LIANG Wencheng, WANG Youchang, LANG Meidong. Preparation and Properties of Polyvinyl Alcohol/ε-Polylysine Hydrogel Wound Dressing[J]. Journal of Functional Polymers, 2022, 35(1): 85-92. doi: 10.14133/j.cnki.1008-9357.20210330002
    Citation: FAN Yao, LIANG Wencheng, WANG Youchang, LANG Meidong. Preparation and Properties of Polyvinyl Alcohol/ε-Polylysine Hydrogel Wound Dressing[J]. Journal of Functional Polymers, 2022, 35(1): 85-92. doi: 10.14133/j.cnki.1008-9357.20210330002

    聚乙烯醇/ε-聚赖氨酸水凝胶伤口敷料的制备及性能

    Preparation and Properties of Polyvinyl Alcohol/ε-Polylysine Hydrogel Wound Dressing

    • 摘要: 在聚乙烯醇(PVA)水溶液中引入ε-聚赖氨酸(ε-PL)和柠檬酸(CA),采用冻融法制备具有抗菌性能的复合水凝胶PVCL。通过傅里叶红外光谱(FT-TR)仪、扫描电子显微镜(SEM)、差示扫描量热(DSC)仪和万能拉伸试验机对复合水凝胶的结构和性能进行表征。采用抗菌活性、溶血率和细胞毒性表征复合水凝胶的生物性能。结果表明,加入CA可以提高PVA水凝胶的力学性能,水凝胶的拉伸强度从1.8 MPa增加到3.0 MPa,断裂伸长率从355.9%增加到426.5%。ε-PL为PVA水凝胶提供了优异的抗菌活性,当ε-PL的质量分数为5%和7%时,PVCL复合水凝胶对大肠杆菌(E.coli)和金黄色葡萄球菌(S.aureus)的抗菌率均接近100%。此外,PVCL复合水凝胶具有优异的血液相容性和细胞相容性。

       

      Abstract: Composite hydrogels PVCL with antibacterial properties were prepared by freeze-thawing method by introducing ε-polylysine(ε-PL) and citric acid (CA) into polyvinyl alcohol (PVA) aqueous solution. The structure and properties of PVCL were characterized by Fourier transform infrared spectroscopy (FT-TR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), universal tensile testing machine and swelling capacity. The biological properties of the composite hydrogels were characterized by antibacterial test, hemolysis test and cytotoxicity test. Results showed that the mechanical properties of PVA hydrogels were improved by adding CA. Compared with pure PVA hydrogel, the tensile strength of hydrogel was increased by 66.7% (from 1.8 MPa to 3.0 MPa), and the elongation at break increased by 19.8% (from 355.9% to 426.5%). However, the addition of ε-PL could reduce the mechanical properties of the hydrogels. The highest swelling rate of the composite hydrogel was 293.7%. ε-PL provided excellent antimicrobial activity for composite hydrogels. The antibacterial rate increased with the increase of ε-PL content, and the highest antibacterial rate against E.coli and S.aureus was close to 100%. In addition, PVCL had excellent hemocompatibility and cytocompatibility.

       

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