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    何元, 罗媛媛, 刘通, 张银山, 郭赞如, 章家立. 温度响应型酰腙可逆共价键水凝胶的制备及性能[J]. 功能高分子学报, 2022, 35(1): 93-100. doi: 10.14133/j.cnki.1008-9357.20210322002
    引用本文: 何元, 罗媛媛, 刘通, 张银山, 郭赞如, 章家立. 温度响应型酰腙可逆共价键水凝胶的制备及性能[J]. 功能高分子学报, 2022, 35(1): 93-100. doi: 10.14133/j.cnki.1008-9357.20210322002
    HE Yuan, LUO Yuanyuan, LIU Tong, ZHANG Yinshan, GUO Zanru, ZHANG Jiali. Preparation and Properties of Temperature-Responsive Hydrogels Based on Acylhydrazone Reversible Covalent Bonds[J]. Journal of Functional Polymers, 2022, 35(1): 93-100. doi: 10.14133/j.cnki.1008-9357.20210322002
    Citation: HE Yuan, LUO Yuanyuan, LIU Tong, ZHANG Yinshan, GUO Zanru, ZHANG Jiali. Preparation and Properties of Temperature-Responsive Hydrogels Based on Acylhydrazone Reversible Covalent Bonds[J]. Journal of Functional Polymers, 2022, 35(1): 93-100. doi: 10.14133/j.cnki.1008-9357.20210322002

    温度响应型酰腙可逆共价键水凝胶的制备及性能

    Preparation and Properties of Temperature-Responsive Hydrogels Based on Acylhydrazone Reversible Covalent Bonds

    • 摘要: 首先,通过可逆加成-断裂转移(RAFT)聚合制备了丙烯酰胺(AM)、双丙酮丙烯酰胺(DAAM)和N-异丙基丙烯酰胺(NIPAM)的共聚物(PAM-co-PDAAM-co-PNIPAM);然后,使PAM-co-PDAAM-co-PNIPAM与己二酸二酰肼(ADH)反应后,得到了具有温度和pH双重响应性的水凝胶。通过核磁共振氢谱(1H-NMR)和凝胶渗透色谱(GPC)、流变仪、扫描电镜(SEM)以及傅里叶变换红外光谱(FT-IR)对共聚物和水凝胶的结构和组成,以及水凝胶的温度和pH双重响应行为进行了研究。研究表明,该水凝胶具有温度调控的自愈合性,对药物阿霉素(Dox)表现出pH和温度双重响应的可控释放行为。

       

      Abstract: A series of PAM-co-PDAAM-co-PNIPAM copolymers were synthesized by reversible addition fracture transfer (RAFT) polymerization from acrylamide (AM), diacetone acrylamide (DAAM) and N-isopropylacrylamide (NIPAM). Their structure and composition were characterized by Nuclear Magnetic Resonance (NMR) and Gel Permeation Chromatography (GPC). Hydrogel with pH and temperature dual-response formed by the acyl hydrazone dynamic bonds between ketocarbonyl in polymer and hydrazide in adipic dihydrazide (ADH). The dual-responsive behavior of hydrogels to temperature and pH was researched by rheological measurement, Scanning Electron Microscope (SEM) and Fourier Transform Infrared (FT-IR) spectroscopy. At the same time, the hydrogel demonstrated temperature controlled self-healing properties. Besides, the hydrogels showed pH-and temperature-responsive controlled release behaviors for doxorubicin(Dox).

       

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