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    张婧楷, 刘潇璇, 李莉莉. 糖肽高分子材料及生物医学应用[J]. 功能高分子学报, 2021, 34(5): 401-417. doi: 10.14133/j.cnki.1008-9357.20210309001
    引用本文: 张婧楷, 刘潇璇, 李莉莉. 糖肽高分子材料及生物医学应用[J]. 功能高分子学报, 2021, 34(5): 401-417. doi: 10.14133/j.cnki.1008-9357.20210309001
    ZHANG Jingkai, LIU Xiaoxuan, LI Lili. Glycopeptide-Based Polymers and Their Biomedical Applications[J]. Journal of Functional Polymers, 2021, 34(5): 401-417. doi: 10.14133/j.cnki.1008-9357.20210309001
    Citation: ZHANG Jingkai, LIU Xiaoxuan, LI Lili. Glycopeptide-Based Polymers and Their Biomedical Applications[J]. Journal of Functional Polymers, 2021, 34(5): 401-417. doi: 10.14133/j.cnki.1008-9357.20210309001

    糖肽高分子材料及生物医学应用

    Glycopeptide-Based Polymers and Their Biomedical Applications

    • 摘要: 糖肽高分子材料是一类由多肽和糖类化合物构成的高分子材料。糖肽高分子材料具有与天然糖肽/糖蛋白类似的化学组成,能够在一定程度上模拟天然糖肽/糖蛋白的结构和功能。本文总结了糖肽高分子材料的合成方法、材料设计及其在生物医学领域的应用,重点综述了糖肽高分子材料在糖肽树形分子、自组装糖肽和糖肽聚合物方面的材料设计,以及糖肽高分子材料在抗菌、抗肿瘤疫苗、仿生支架、组织及软骨修复方面的应用。最后,对糖肽高分子材料的发展与前景进行了展望。

       

      Abstract: Glycopeptide-based polymers are a kind of biodegradable polymers composed of polypeptides and carbohydrates. Owing to their chemical similarity to natural glycopeptides and glycoproteins, they can mimic the structure and function of natural products. There are two main types of glycosides: N-glycosides and O-glycosides. Glycosides are coupled with amino acids in advance to form glycosylated amino acid building blocks, and then participate in the synthesis of glycopeptides together with amino acids in solid phase synthesis. Native chemical ligation is often used to synthesize longer glycopeptide that cannot be obtained by solid phase synthesis. Glycopeptides are designed to reflect multivalence, so the most common types include branched glycopeptides, self-assembled glycopeptides and polymer glycopeptides. Branched glycopeptides mainly include glycopeptide dendrimers. Self-assembled glycopeptides mainly consist of modifying various glycosyl groups on self-assembled polypeptides. Based on these self-assembled glycopeptides, glycopeptide materials can self-assemble into various nanostructures, such as micelles, vesicles, fibers and nanorods. As a kind of structural mimic of natural glycoproteins, synthetic glycopeptides can play a variety of biomedical roles. Synthetic glycopeptides are capable of binding to lectin or adhesive of bacteria or targeting intracellular bacteria of macrophages. Due to the overexpression of carbohydrate-binding proteins on tumor cells surfaces, glycopeptides have been widely investigated as an anti-tumor vaccine. In addition, glycopeptide-based hydrogels can be used as a biomimetic scaffold for mammalian cells growth due to their high-water content and similar structure, shape and composition to the extracellular matrix (ECM) in tissues. Glycopeptides can also simulate natural glycosaminoglycans to play a role in tissue and cartilage repair. We summarize the synthesis method, material design and biomedicine application of glycopeptides, focusing on the material design of glycopeptides in branched glycopeptides, self-assembled glycopeptides and polymer glycopeptides, and the applications of glycopeptides in antibacterial, anti-tumor vaccine, bionic scaffold, tissue and cartilage repair.

       

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