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    臧靖, 柯学, 慈天元. 肝素在抗肿瘤药物递送系统中的应用[J]. 功能高分子学报, 2021, 34(3): 215-229. doi: 10.14133/j.cnki.1008-9357.20200824001
    引用本文: 臧靖, 柯学, 慈天元. 肝素在抗肿瘤药物递送系统中的应用[J]. 功能高分子学报, 2021, 34(3): 215-229. doi: 10.14133/j.cnki.1008-9357.20200824001
    ZANG Jing, KE Xue, CI Tianyuan. Application of Heparin in Anti-Tumor Drug Delivery Systems[J]. Journal of Functional Polymers, 2021, 34(3): 215-229. doi: 10.14133/j.cnki.1008-9357.20200824001
    Citation: ZANG Jing, KE Xue, CI Tianyuan. Application of Heparin in Anti-Tumor Drug Delivery Systems[J]. Journal of Functional Polymers, 2021, 34(3): 215-229. doi: 10.14133/j.cnki.1008-9357.20200824001

    肝素在抗肿瘤药物递送系统中的应用

    Application of Heparin in Anti-Tumor Drug Delivery Systems

    • 摘要: 肝素是一种高度硫酸化的糖胺聚糖,目前主要作为抗凝剂应用于临床。肝素具有一定的抗肿瘤转移的作用,而基于肝素此项功能的抗肿瘤药物递送系统亦被广泛研究。在这类药物传递系统中,肝素一方面可增强抗肿瘤药物的抑瘤效果,同时亦可发挥自身的抗肿瘤转移功能,使药物及载体协同作用。基于肝素的抗肿瘤转移作用机理及肝素在药物递送系统中的应用,围绕相关的设计思路与方法展开综述,以期为相关领域的研究提供参考。

       

      Abstract: Heparin is a kind of glycosaminoglycan with complex structure, which is composed of glucuronic acid and glucosamine. Even though heparin has been used as anticoagulant in clinic for long time, growing evidence have indicated its potent capability in anti-metastasis. In recent years, heparin-based anti-tumor drug delivery system has been widely reported. In these systems, heparin not only enhances the anti-tumor effect of anticancer drugs, but also exhibits its own anti-metastasis function, realizing synergistic anti-tumor and anti-metastasis effects between drugs and drug vesicles. Generally, the heparin-based drug delivery system can be divided into nano-based drug delivery system, micro-based drug delivery system and hydrogel. Here we review the rational design of these systems and discuss the potential challenges in this field.

       

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