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    林柏仲, 赵丽, 王宏伟, 朱浩鹏, 盖广清, 王立艳, 丁建勋. 生物黏合水凝胶研究进展[J]. 功能高分子学报, 2020, 33(2): 125-140. doi: 10.14133/j.cnki.1008-9357.20190711001
    引用本文: 林柏仲, 赵丽, 王宏伟, 朱浩鹏, 盖广清, 王立艳, 丁建勋. 生物黏合水凝胶研究进展[J]. 功能高分子学报, 2020, 33(2): 125-140. doi: 10.14133/j.cnki.1008-9357.20190711001
    LIN Bozhong, ZHAO Li, WANG Hongwei, ZHU Haopeng, GAI Guangqing, WANG Liyan, DING Jianxun. Progress in Bioadhesive Hydrogels[J]. Journal of Functional Polymers, 2020, 33(2): 125-140. doi: 10.14133/j.cnki.1008-9357.20190711001
    Citation: LIN Bozhong, ZHAO Li, WANG Hongwei, ZHU Haopeng, GAI Guangqing, WANG Liyan, DING Jianxun. Progress in Bioadhesive Hydrogels[J]. Journal of Functional Polymers, 2020, 33(2): 125-140. doi: 10.14133/j.cnki.1008-9357.20190711001

    生物黏合水凝胶研究进展

    Progress in Bioadhesive Hydrogels

    • 摘要: 近年来,水凝胶在组织工程支架、伤口敷料和药物递送系统等生物医学领域得到广泛应用。其中,生物黏合水凝胶因具有良好的黏合强度和优异的生物相容性,并且可以替代传统的手术缝合用于止血及伤口处理而备受关注。本文在已有工作的基础上系统地概述了生物黏合水凝胶的制备方法,并详细地讨论了各种水凝胶的黏合机理。此外,总结了生物黏合水凝胶在生物医学中的应用,并展望了性能优异的生物黏合水凝胶的开发思路。

       

      Abstract: Over the past few decades, the suture has been the practice of choice for wound management, which held the tissues in close proximity for fast healing and stopped body fluid leakage. However, the suture is not ideal and not suitable for many procedures owing to the inherent invasion of sutures. Complete sealing of incisions by sutures may cause additional damage to the surrounding tissues of surgical sites. In addition, the incision closure using sutures requires a specific technical skill of the surgeons, which influences the duration and success of the operation. Moreover, the suture-enclosed wounds have a higher infection rate and face the subsequent removal of the suture. To solve these problems, medical adhesives have emerged as attractive alternatives to suturing due to their facile application. The medical adhesive is an atraumatic, fast, and painless method for wound management, which exhibits effective hemostasis, efficient prevention of body fluid leakage, strong tissue bonding, and minimal scarring. Surgical materials for medical adhesives should be biocompatible, biodegradable, and inexpensive. In this regard, bioadhesive hydrogels have attracted growing attention owing to excellent properties, including high adhesive strength and fast curing capability. The preparation methods of bioadhesive hydrogels are summarized in this review. The adhesion mechanism of bioadhesive hydrogel is usually the combination of multiple interactions with one interaction being dominant. In addition, the biomedical applications of bioadhesive hydrogels are introduced, and the development of bioadhesive hydrogels with unique properties is also predicted.

       

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