高级检索

    童艳萍, 肖艳. 双重动态化学键交联水凝胶的制备及性能[J]. 功能高分子学报, 2020, 33(3): 305-312. doi: 10.14133/j.cnki.1008-9357.20190430002
    引用本文: 童艳萍, 肖艳. 双重动态化学键交联水凝胶的制备及性能[J]. 功能高分子学报, 2020, 33(3): 305-312. doi: 10.14133/j.cnki.1008-9357.20190430002
    TONG Yanping, XIAO Yan. Preparation and Properties of Dual Dynamic Covalent Bond Crosslinked Hydrogels[J]. Journal of Functional Polymers, 2020, 33(3): 305-312. doi: 10.14133/j.cnki.1008-9357.20190430002
    Citation: TONG Yanping, XIAO Yan. Preparation and Properties of Dual Dynamic Covalent Bond Crosslinked Hydrogels[J]. Journal of Functional Polymers, 2020, 33(3): 305-312. doi: 10.14133/j.cnki.1008-9357.20190430002

    双重动态化学键交联水凝胶的制备及性能

    Preparation and Properties of Dual Dynamic Covalent Bond Crosslinked Hydrogels

    • 摘要: 设计并制备了具有良好水溶性且带有酰肼基团的聚(肌氨酸-co-谷氨酸酰肼)(P(Sar-co-GH))以及带有醛基的氧化海藻酸钠(OSA)。在温和的条件下,P(Sar-co-GH)、OSA、羧甲基壳聚糖(CMC)可通过酰腙键和亚胺键交联快速制得双重动态化学键交联的水凝胶。采用红外光谱、旋转流变仪对水凝胶的结构和力学性能及形貌进行了表征。结果表明:酰腙键和亚胺键的交联赋予了水凝胶可注射性、pH响应性和自修复性。体外细胞毒性和细胞3D培养实验表明水凝胶具有良好的生物相容性并且能够支持细胞的生长与增殖。

       

      Abstract: Poly(sarcosine-co-glutamate hydrazide) (P(Sar-co-GH)) with good water solubility and hydrazide group and oxidized sodium alginate (OSA) with aldehyde group were designed and prepared. Under mild conditions, hydrogels composed of P(Sar-co-GH), OSA and carboxymethyl chitosan (CMC) could be prepared based on acylhydrazone bonds formed between P(Sar-co-GH) and OSA and imine bonds formed between CMC and OSA. The structure and mechanical properties of the hydrogels were characterized by FT-IR and rotational rheometer. Results show that the mechanical properties of hydrogels can be adjusted from 840 Pa to 5 690 Pa by changing the content of P(Sar-co-GH) and CMC. The double dynamic chemical bond hydrogel can be injected by the 23 G needle and also exhibit the self-healing behavior within 12 h. Moreover, the hydrogels can undergo repeated gel-sol transition under the regulation of triethylamine(TEA) and hydrochloric acid(HCl). In vitro cytotoxicity and cell culture experiments demonstrate that copolymer and hydrogel extract are nontoxic to mouse embryonic cells(NIH/3T3) and can support NIH/3T3 growth and proliferation. Overall, a new hydrogel based on polypeptide and polysaccharide is developed by dual dynamic covalent bond, which endows the material with injectability, self-healing properties and pH responsiveness and has great potential in biomedical field.

       

    /

    返回文章
    返回