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    刘涛, 冯俊, 张先正. 用于肿瘤诊疗的金属-多酚网络多功能材料[J]. 功能高分子学报, 2019, 32(4): 421-433. doi: 10.14133/j.cnki.1008-9357.20181114001
    引用本文: 刘涛, 冯俊, 张先正. 用于肿瘤诊疗的金属-多酚网络多功能材料[J]. 功能高分子学报, 2019, 32(4): 421-433. doi: 10.14133/j.cnki.1008-9357.20181114001
    LIU Tao, FENG Jun, ZHANG Xianzheng. Metal-Polyphenol Network Based Multifunctional Materials for Theranostic Applications[J]. Journal of Functional Polymers, 2019, 32(4): 421-433. doi: 10.14133/j.cnki.1008-9357.20181114001
    Citation: LIU Tao, FENG Jun, ZHANG Xianzheng. Metal-Polyphenol Network Based Multifunctional Materials for Theranostic Applications[J]. Journal of Functional Polymers, 2019, 32(4): 421-433. doi: 10.14133/j.cnki.1008-9357.20181114001

    用于肿瘤诊疗的金属-多酚网络多功能材料

    Metal-Polyphenol Network Based Multifunctional Materials for Theranostic Applications

    • 摘要: 多酚广泛存在于自然界的各种植物中,具有抗癌、抗血栓以及其他保健功效。金属离子在生物和化学催化领域以及各种疾病的检测和治疗中起着非常重要的作用。金属离子和多酚能方便快捷地自组装成金属-多酚网络,其简单绿色的组装制备过程以及对各种实体表面的黏附特性使其在仿生学、材料学和生物医学等领域凸显出巨大的应用潜力。本文总结了近年来金属-多酚类纳米材料在生物医用方面的探索和应用,介绍了本课题组关于金属-多酚网络在肿瘤诊疗方面的研究工作,并对金属-多酚类纳米材料的发展趋势进行了展望。

       

      Abstract: Polyphenols are widely spread in nature especially in plants. Many polyphenols have been approved by the FDA with the widespread utilization in food and medicine. Metal ions have found important applications in the fields of biocatalysis and chemical catalysis, bioimaging, diagnosis and disease treatment, etc. The digalloyl groups rich in polyphenols can serve as chelating sites for multivalent metal ions to induce rapid self-crosslinking of polyphenols, giving rise to stable metal-polyphenol networks (MPN) without heat treatment, use of organic solvents and special instruments or additive chemicals. Metal-polyphenol networks share the excellent adhesion capability with parent polyphenols, thus readily adhere to various interfaces of different substrates (e.g., polymeric and inorganic materials, cells, proteins, virus, bacteria, yeast), regardless of the origins, shapes and structures. By taking advantage of the selected templates (e.g., 2D materials, solid sphere/rod, hollow vesicle, nanowires, nanosheets, nanocubes), various nanostructures coated with metal-polyphenol networks are easily accessible as desired. This unique characteristic can function as an intermediate to bridge the intrinsic properties of metal-polyphenol networks to the versatile functions of nanotemplates, such as the loading capacity of various cargoes (e.g. hydrophobic/hydrophilic, low molecular weight/macromolecular, and artificial/natural substances). The abundant phenol groups in polyphenols also allow for surface modification through chemical conjugation, π-π stacking and so on. In addition, the environment-responsive conversion between the self-assembled and the disassociated metal-polyphenol networks endows these materials with great potential for drug delivery. This supramolecular self-assembly network with facile and green preparation process can be developed as a kind of multifunctional nanoplatforms for advanced applications in the fields of bionics, materials science, and biomedicine, particularly for diagnosis and treatment of tumor. In this review, we have summarized the recent development of metal-polyphenol nanomaterials for biomedical applications, including a brief introduction of the related work that has been performed by our research group.

       

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