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    周浩浩, 曹慧群, 周莉, 罗仲宽, 胡惠媛, 黄丹榕. 多孔载药n-HA/PEEK/CS复合材料的制备与性能[J]. 功能高分子学报, 2018, 31(3): 267-272. doi: 10.14133/j.cnki.1008-9357.20171105002
    引用本文: 周浩浩, 曹慧群, 周莉, 罗仲宽, 胡惠媛, 黄丹榕. 多孔载药n-HA/PEEK/CS复合材料的制备与性能[J]. 功能高分子学报, 2018, 31(3): 267-272. doi: 10.14133/j.cnki.1008-9357.20171105002
    ZHOU Hao-hao, CAO Hui-qun, ZHOU Li, LUO Zhong-kuan, HU Hui-yuan, HUANG Dan-rong. Preparation and Properties of Porous Drug-Delivery n-HA/PEEK/CS Composite Materials[J]. Journal of Functional Polymers, 2018, 31(3): 267-272. doi: 10.14133/j.cnki.1008-9357.20171105002
    Citation: ZHOU Hao-hao, CAO Hui-qun, ZHOU Li, LUO Zhong-kuan, HU Hui-yuan, HUANG Dan-rong. Preparation and Properties of Porous Drug-Delivery n-HA/PEEK/CS Composite Materials[J]. Journal of Functional Polymers, 2018, 31(3): 267-272. doi: 10.14133/j.cnki.1008-9357.20171105002

    多孔载药n-HA/PEEK/CS复合材料的制备与性能

    Preparation and Properties of Porous Drug-Delivery n-HA/PEEK/CS Composite Materials

    • 摘要: 首先以纳米羟基磷灰石(n-HA)、聚醚醚酮(PEEK)、壳聚糖(CS)为原材料进行复合,制得n-HA/PEEK/CS复合材料;然后采用聚乙烯吡咯烷酮(PVP)/NaCl作为致孔剂对复合材料进行致孔,载入抗生素类药物红霉素(EM),制备出一种新型多孔载药复合骨修复材料n-HA/PEEK/CS/EM。通过傅里叶红外光谱(FT-IR)、扫描电镜(SEM)、力学测试、紫外-可见分光光度计(UV-Vis)表征了该复合材料的形貌结构、力学性能及药物缓释性能。结果表明:当m(PVP):m(NaCl)=1:6时,可以得到孔隙率为51.6%、抗压强度为6.98 MPa的n-HA/PEEK/CS/EM复合材料;当CS的质量分数由0增加到30%时,最大药物释放质量浓度由39.8 μg/mL增加到52.0 μg/mL;药物载入后无新化学键生成;材料形成了三维立体多孔结构,孔径为5~50 μm,有利于营养物质的运输及细胞、组织的长入。

       

      Abstract: Firstly, n-HA/PEEK/CS (nano-hydroxyapatite/polyether ether ketone/chitosan) composite materials were prepared using nano-hydroxyapatite (n-HA), polyether ether ketone (PEEK) and chitosan (CS) as raw materials. Then the drug-delivering bone-repair materials were synthesized via forming holes using polyvinylpyrrolidone (PVP) and sodium chloride (NaCl) as the porogen and loading the antibiotic erythromycin (EM) into the n-HA/PEEK/CS composite material. By adjusting the dosage of PVP, the composite materials with different porosities were obtained. The morphology and structure of the as-prepared composite materials were characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscope (SEM). The mechanical properties of the composite materials were tested by mechanical measurements, with the compressive strength and the brittle broken degrees of the composite materials being measured under specified test conditions respectively, the drug release performance of the composite materials being investigated by stirring basket method, and the dissolution rate of erythromycin in composite materials being determined by Ultraviolet Visible Spectrophotometer (UV-Vis). Results showed that with the augment of the PVP content, the porosity of the composite materials increased. The n-HA/PEEK/CS/EM composite material was obtained with a porosity of 51.6% and a compressive strength of 6.98 MPa when PVP and NaCl were used in a mass ratio of 1:6, which was approaching cancellous bone. When the mass fraction of the CS within the composite material was increased from 0 to 30%, the maximum drug release concentration increased from 39.8 μg/mL to 52.0 μg/mL. The release rate of the process could be adjusted by turning the pore size of composite materials, and the maximum drug release concentration could be controlled by altering the content of chitosan in composite materials. There was no new chemical bond generation after loading the antibiotic erythromycin (EM). The composite materials formed three-dimensional porous structures and the pore diameter was between 5 μm and 50 μm, which met the requirement of artificial bone aperture, and would benefit the transportation of nutrients and the growth of cells and tissues.

       

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