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硬段含二硫键聚氨酯复合材料的生物骨黏合性

肖伟 刘欣畅 郑震 王新灵 肖海军

肖伟, 刘欣畅, 郑震, 王新灵, 肖海军. 硬段含二硫键聚氨酯复合材料的生物骨黏合性[J]. 功能高分子学报. doi: 10.14133/j.cnki.1008-9357
引用本文: 肖伟, 刘欣畅, 郑震, 王新灵, 肖海军. 硬段含二硫键聚氨酯复合材料的生物骨黏合性[J]. 功能高分子学报. doi: 10.14133/j.cnki.1008-9357
XIAO Wei, LIU Xinchang, ZHENG Zhen, WANG Xinling, XIAO Haijun. Research on Biological Bone Adhesion Properties of Polyurethane Composite with Disulfide Bond in Hard Segment[J]. Journal of Functional Polymers. doi: 10.14133/j.cnki.1008-9357
Citation: XIAO Wei, LIU Xinchang, ZHENG Zhen, WANG Xinling, XIAO Haijun. Research on Biological Bone Adhesion Properties of Polyurethane Composite with Disulfide Bond in Hard Segment[J]. Journal of Functional Polymers. doi: 10.14133/j.cnki.1008-9357

硬段含二硫键聚氨酯复合材料的生物骨黏合性

doi: 10.14133/j.cnki.1008-9357
基金项目: 精准医学创新基金(IFPM2019 B001)
详细信息
    作者简介:

    肖伟:肖 伟(1996—),男,湖北襄阳人,硕士生,主要研究方向为聚氨酯胶黏剂。E-mail:1024463868@qq.com

    通讯作者:

    郑 震,E-mail:zzheng@sjtu.edu.cn ;肖海军,E-mail:xiaohaijun89@126.com

  • 中图分类号: TQ323.8

Research on Biological Bone Adhesion Properties of Polyurethane Composite with Disulfide Bond in Hard Segment

  • 摘要: 通过卤代烃的亲核取代反应合成了一种含二硫键的脂肪族二元醇(DSU),将其以硬段形式引入到聚氨酯分子中,制备了一系列二硫键改性的聚氨酯复合材料。通过核磁确定了DSU的化学结构,采用万能电子试验机、扫描电子显微镜等测试了DSU用量对聚氨酯的压缩力学性能、水接触角、微观形貌和黏接强度等性能的影响。结果表明,当DSU用量为改性蓖麻油多元醇的10 wt.%时,材料表现出较好的综合性能,骨黏接强度为0.97 MPa,压缩强度为7.0 MPa,压缩模量为41.3 MP,新鲜兔血液中骨黏接强度为0.49 MPa。体外大鼠骨髓间充质干细胞培养实验表明,材料具有良好的细胞相容性,其多孔结构有利于细胞的增殖和黏附,有望应用于医用骨胶黏剂领域。

     

  • 图  1  HO―(CH2)6―S―S―(CH2)6―OH(DSU)的合成

    Figure  1.  The synthesis of diols containing a disulfide bond (DSU)

    图  2  6-溴-1-己醇(左图)和HO―(CH2)6―S―S―(CH2)6―OH(右图)的1H-NMR谱图

    Figure  2.  The 1H-NMR spectra of 6-bromo-1-hexanol and DSU

    图  3  DSU含量对聚氨酯力学性能的影响:a)压缩强度,b)压缩模量

    Figure  3.  The effect of DSU content on the compressive property of polyurethane adhesives: a) compressive strength and b) compressive modulus

    图  4  不同DSU含量下聚氨酯SEM图:a) PU-DSU-0, b) PU-DSU-5, c) PU-DSU-10, d) PU-DSU-15, e) PU-DSU-20

    Figure  4.  SEM topographies of polyurethane adhesives with different DSU content: a) PU-DSU-0, b) PU-DSU-5, c) PU-DSU-5, d) PU-DSU-15, e) PU-DSU-20

    图  5  不同DSU含量下聚氨酯胶黏剂水接触角

    Figure  5.  Water contact angle of polyurethane adhesives with different DSU content

    图  6  不同DSU含量下聚氨酯胶黏剂骨黏接强度

    Figure  6.  The bone bonding strength of polyurethane adhesives with different DSU content

    图  7  PU-DSU-10在不同浓度GSH溶液中的降解曲线

    Figure  7.  The degradation of PU-DSU-10 in GSH solutions with different concentration

    图  8  PU-DSU-10的生物相容性:a)不同培养时长后的细胞活性;b)培养3天后和c)培养5天后的细胞形态

    Figure  8.  Biocompatibility of PU-DSU-10: a) Cell activity at different time; cell morphology after b) 3 days and c) 5 days of culture

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出版历程
  • 录用日期:  2022-04-27
  • 网络出版日期:  2022-05-07

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