壳聚糖-O-聚（寡聚乙二醇甲基丙烯酸酯）的原子转移自由基聚合与表征

Chitosan-O-Poly(oligo(ethylene glycol) methacrylate)Brush Polymers:ATRP Synthesis and Characterization

摘要: 基于原子转移自由基聚合（ATRP）和十二烷基硫酸钠(SDS)壳聚糖（CS）复合物（SCC）的位置选择性改性策略，合成了结构可控的壳聚糖-O-聚（寡聚乙二醇甲基丙烯酸甲酯）（CSPOEGMA）刷状衍生物。通过在SCC的羟基上引入溴代异丁酸后脱除SDS得到大分子引发剂O溴化壳聚糖（CS-Br）。用红外光谱（FT-IR）与核磁共振（1HNMR）表征了产物结构。结果表明：改变溴代度（DS）可调节聚（寡聚乙二醇甲基丙烯酸甲酯）（POEGMA）的接枝度，而改变寡聚乙二醇甲基丙烯酸甲酯（OEGMA）与CSBr

Abstract: Chitosanderived brush polymers with welldefined chemical structure were synthesized by combining ATRP with sodium dodecyl sulphatechitosan complex (SCC)based regioselective modification strategy. ATRP macromolecular initiator, O-bromobutyrated CS (CS-Br), was conveniently prepared by grafting bromoisobutyrate onto the hydroxy groups of SCC and subsequently removing SDS from the Obromobutyrated SCC. The structure of product was characterized by FTIR and 1HNMR. Results showed that the grafting level of POEGMA could be adjusted by varying the degree of substitution (DS) of bromobutyrate. By changing molar feeding ratio of OEGMA to CSBr, the degree of polymerization of POEGMA could be modulated.