Abstract: Poly(ε-caprolactone)natural bone powder (PCL-BP) composites with varying bone powder contents were prepared by meltblending method and characterized through mechanical, DSC, TGA, and surface wettability experiments. Results show that the tensile and flexural strength of PCL-BP composites increase at first and then decrease with the increasing of BP content. The surface wettability of PCLBP composites is improved by the addition of BP. Furthermore, the crystallization temperature of PCL-BP composites increases, while the melting enthalpy and thermal stability decrease.