聚N,N-二乙基丙烯酰胺温敏水凝胶的药物释放研究

Study on Drug Release from Poly(N,N-diethylacrylamide) (PNDEA) Thermosensitive Hydrogels

摘要: 在合成聚Ｎ，Ｎ－二乙基丙烯酰胺温敏水凝胶的基础上研究了该水凝胶在ＬＣＳＴ附近对药物的释放（以氟哌酸为主）。温度与交联度的变化对药物的释放皆有明显的影响。通过对释放曲线进行计算机模拟得到释放液浓度的经验公式，并从理论上初步解释了公式中各参数的物理意义。作出了理论近似计算得到的表观扩散系数的变化曲线，其在ＬＣＳＴ附近各温度的变化趋势符合预测

Abstract: Poly(N,N-diethylacrylamide) thermosensitive hydrogels were prepared with N,N'-methylenebisacrylamide as crosslinker in a norfloxacin solution to uptake the drug simultaneously. Releasing mechanism of Norfloxacin/PNDEA drug-delivery system was discussed in