布洛芬高分子前体药物及纳米微球的合成和表征
Synthesis and Characterization of Polymeric Drug Containing Brufen and its Nano-sphere
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摘要: 将非甾体消炎药布洛芬以共价键连接到舍双键的甲基丙烯酸-2-羟基乙酯(HEMA)上，制成含布洛芬药物的单体，进而通过自聚或共聚，合成了含布洛芬的高分子药物；采用乳液聚合方法制备了高分子药物蚋米微球。研究了影响聚合反应的有关因素，并对所合成的产物用^1H-NMR，GPC和TEM等检测手段进行了表征。Abstract: Brufen,a nonsteroidal anti-inflammatory drug,was linked with 2-hydroxyethyl methacrylate (HEMA)through covalent linkage,the drug-linked HEMA(monomer)was homopolymerized or copolymerized to obtain polymeric drug.The polymeric nano-spheres were prepared by
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