呋喃甲酰壳聚糖的制备、表征及其抗氧化活性

Synthsis, Characterization and Antioxidant Activity of N-Furoyl Chitosan

摘要: 以壳聚糖与呋喃甲酰氯反应得到呋喃甲酰壳聚糖。通过FT-IR、1H-NMR、X射线衍射、热重分析、溶解度实验、元素分析、抗氧化活性测试等手段对产物进行了结构和性能表征。结果表明：产物为目标产物且热稳定性好于壳聚糖；在水中的溶解性能良好，溶解度为0.04 g/mL；取代度为0.69；当对羟基自由基的清除率达到50%时，呋喃甲酰壳聚糖的质量浓度为 1.1 mg/mL，其还原能力随质量浓度增加而增强，抗氧化活性优于壳聚糖。

Abstract: N-furoyl chitosan was synthesized by the reaction of chitosan with the furoyl chloride. The structure and performance of the product was characterized by FT-IR, 1H-NMR, XRD, thermogravimetric analysis (TGA), solubility analysis, elemental analysis, antioxidant activity analysis. Results showed that the product was N-furoyl chitosan and the thermal stability of product was superior to chitosan and the solubility was 0.04 g/mL in water. The degree of substitution was 0.69. When hydroxyl radicals clearance rate reached 50%, the mass concentration of furoyloxy chitosan was 1.1 mg/mL. The reducing power of chitosan and product increased with their mass concentration increasing. The antioxidant activity of N-furoyl chitosan was stronger than that of chitosan.