一种新型三肽衍生物改性聚氨酯的合成和应用

Synthesis and Application of Polyurethanes Modified by a Novel tri-Peptide Derivative

摘要: 合成了一种新型三肽衍生物苯丙氨酸赖氨酸乙酯苯丙氨酸（PLP)。以PLP为扩链剂、聚己内酯二醇(PCL)为软段、4,4′-二环己基甲烷二异氰酸酯(HMDI)为硬段，合成了一系列不同三肽含量的聚氨酯(PUPLP)。通过1H-NMR、FT-IR、TG、DSC和黏接强度等对PLP和PU-PLP的结构和性能进行了研究。结果表明：PLP以及PUPLP的结构与预期相符；相比1,4-丁二醇(BDO)扩链的聚氨酯，PU-PLP的黏接强度更高。

Abstract: A novel tri-peptide derivative, phenylalanine-lysine-ethyl-ester-phenylalanine (PLP), was synthesized. A series of polyurethanes (PU-PLP) with different PLP contents were synthesized using PLP as chain extender, polycaprolactone (PCL) with different molecular weights as soft segment and dicyclohexylmethane 4,4′-diisocyanate (HMDI) as hard segment. The structures of PLP·2HCl and PU-PLP were characterized by 1H-NMR and FT-IR. The properties of PU-PLP were tested by DSC、TGA and bonding strength. Results show that the structures of PLP and PU-PLP appear to be well proven. Compared with BDOextended polyurethanes, PLPextended polyurethanes (PU-PLP) shows relatively higher adhesive ability.