两亲型羧甲基壳聚糖衍生物的合成及体外药物释放

Synthesis and Drug Release Behavior of Amphiphilic Carboxymethylchitosan Derivatives

摘要: 通过羧甲基壳聚糖与醛和乳糖反应制得N-烷基乳糖基-O,N-羧甲基壳聚糖,并以戊二醛为交联剂制成水凝胶;以人血清蛋白作为模型药物,初步探讨了该水凝胶对蛋白类药物的释放规律。结果表明:该水凝胶具有亲水-疏水两亲性和不同于壳聚糖的pH敏感性,有望应用于蛋白类药物的控制释放。

Abstract: N-alkyl-lactosylated-O,N-carboxymethyl chitosan are prepared by carboxymethyl-chitosan with alkyldehyde and lactose.Hydrogels based on these materials were synthesized by using glutaraldehyde as cross-linking agent.The effects of various factors on the sw