聚氯乙烯表面共价键合肝素及抗凝血性的研究
Study of Covalent Immobilization of Heparin onto the Surface of Poly(vinyl chloride) for Antithrombogenicity
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摘要: 采用Ar等离子体引发聚乙二醇(PEG)在聚氯乙烯(PVC)表面固定化,进一步对固定PEG后的PVC进行肝素化处理,以改善PVC材料的抗凝血性能。探讨了PEG浓度对Ar等离子体固定化反应效果的影响。通过X射线光电子能谱(XPS)、衰减全反射红外光谱(ATR-FTIR)、扫描电镜(SEM)和接触角测定研究了固定PEG前后PVC的表面性能和表面形貌的变化。XPS分析证实肝素已成功地共价键合于PVC表面。采用体外凝血时间测定和血小板粘附实验对材料的抗凝血性能进行评价,结果表明,被修饰PVC材料的抗凝血性能显著提高。Abstract: Poly(ethylene glycol) (PEG) was immobilized onto the surface of Poly(vinyl chloride) (PVC) by the argon plasma-induced reaction, followed by a reaction with heparin to improve the antithrombogenicity of PVC. The effect of PEG concentration on immobilizing