含多巴胺的聚柠檬酸酯基组织胶黏剂的制备

摘要: 通过柠檬酸、1,8-辛二醇和多巴胺的一步熔融缩聚反应，以高碘酸钠（NaIO4）作为氧化交联剂，得到含有多巴胺的组织胶黏剂。探索了制备胶黏剂的最佳反应时间和多巴胺的最佳添加量，并利用凝胶渗透色谱（GPC）、红外光谱（FT-IR）、核磁共振氢谱（1H-NMR）、紫外可见分光光度法（UV-Vis）和黏结强度测试对胶黏剂的结构和性能进行了表征。结果表明：当反应时间为105 min，柠檬酸、1,8-辛二醇和多巴胺的投料的物质的量之比为1.1∶1.0∶0.5时，可以得到黏结强度为99.3 kPa的组织胶黏剂，达到商品α-氰基丙烯酸酯医用胶强度的40%。

Abstract: A new kind of dopamine containing tissue adhesive was obtained by melt polycondensation of citric acid, 1,8-octadiol and dopamine using NaIO4 as curing agent. The optimal reaction time and dopamine loading were explored. The structure and adhesive strength were characterized using GPC, FT-IR, 1H-NMR, UV-Vis and lap shear strength test. Results showed that the bioadhesive with better adhesive strength (99.3 kPa) was obtained when the reaction time was 105 min and the feeding mole ratio of citric acid, 1,8 octanediol and dopamine was 1.1∶1.0∶0.5, which was 40% of adhesive strength of commercial α-cyanoacrylate adhesive.