Abstract: The management of bacterial bioburden and the modulation of the intricate inflammatory milieu remain the primary hurdles in achieving effective healing of infected wounds. In this study, silver-based metal-organic framework (Ag MOF) and copper-based metal-organic framework (Cu MOF) were synthesized using nicotinic acid as the sole ligand. The two MOFs were subsequently loaded into a photosensitive glycidyl methacrylate-grafted poly (vinyl alcohol) (PVA-GMA, abbreviated as PG) hydrogel to construct a multifunctional composite hydrogel dressing (denoted as Ag/Cu MOFs@PG) with spatiotemporally-controlled release characteristics. Physicochemical characterization demonstrated that the MOFs were uniformly dispersed within the PG hydrogel and exhibited stable and controlled release behavior. Biological evaluations confirmed that the Ag/Cu MOFs@PG hydrogel achieved highly efficient antibacterial activity through the rapid release of Ag⁺. Moreover, it inhibited M1 while promoting M2 macrophage polarization. Simultaneously, the sustained release of Cu²⁺ facilitated endothelial cell migration and tube formation on Matrigel. This multifunctional composite hydrogel, integrated with antibacterial, anti-inflammatory, and pro-angiogenic properties, holds significant potential for the clinical treatment of infected wounds.