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    栾轲, 班雨, 施德安, 石恒冲. 医用高分子材料抗凝血表面构建策略及研究进展[J]. 功能高分子学报, 2021, 34(2): 172-181. doi: 10.14133/j.cnki.1008-9357.20201226001
    引用本文: 栾轲, 班雨, 施德安, 石恒冲. 医用高分子材料抗凝血表面构建策略及研究进展[J]. 功能高分子学报, 2021, 34(2): 172-181. doi: 10.14133/j.cnki.1008-9357.20201226001
    LUAN Ke, BAN Yu, SHI Dean, SHI Hengchong. Construction Strategy and Research Progress of Anticoagulant Surface of Medical Polymeric Materials[J]. Journal of Functional Polymers, 2021, 34(2): 172-181. doi: 10.14133/j.cnki.1008-9357.20201226001
    Citation: LUAN Ke, BAN Yu, SHI Dean, SHI Hengchong. Construction Strategy and Research Progress of Anticoagulant Surface of Medical Polymeric Materials[J]. Journal of Functional Polymers, 2021, 34(2): 172-181. doi: 10.14133/j.cnki.1008-9357.20201226001

    医用高分子材料抗凝血表面构建策略及研究进展

    Construction Strategy and Research Progress of Anticoagulant Surface of Medical Polymeric Materials

    • 摘要: 医用高分子材料及医疗器械主要用于疾病的诊断和治疗。此种材料/器械在植/介入人体与血液接触时,血浆蛋白会在几秒钟内吸附到材料/器械表面,并与血小板上的糖蛋白受体结合,导致血小板活化、凝血级联以及补体激活,形成凝血及血栓,严重危及病人的健康及生命安全。为了赋予材料/器械表面抗凝血性能,需有针对性地进行抗凝血表面构建,其方法主要为:生物惰性涂层、生物活性涂层、具有内皮(EC)特异性生长因子的表面涂层和复合抗凝涂层。本文结合国内外该领域研究动态及本课题组近年来在医用高分子材料及医疗器械抗凝血表面构建的研究成果,概述了抗凝血表面构建及其在医疗器械中应用的研究进展。

       

      Abstract: Biomedical polymer materials and medical devices are mainly used for the diagnosis and treatment of diseases, and are used by thousands of patients every day. When this material/device is implanted/intervened in the human body and comes into contact with blood, plasma proteins will adsorb to the surface of the material/device within a few seconds and bind to the glycoprotein receptor on the platelet, resulting in platelet activation, coagulation cascade and complement activation, coagulation and thrombus. Human health and life safety are seriously endangered. To impart anticoagulant properties to the surface of materials/devices, it is necessary to construct anticoagulant surfaces in a targeted manner. The main methods are as follows: biologically inert coatings, biologically active coatings, surface coatings with endothelial (EC) specific growth factors, and composite anti-coagulation coating. Based on the research developments in this field at home and abroad and the research results of our group in recent years in the construction of anticoagulant surface of biomedical polymer material and medical device, this review summarizes the research progress of anticoagulant surface construction and its application in medical devices.

       

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