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pH-磁双响应Janus笼

纪旭阳 张杨 梁福鑫

纪旭阳, 张杨, 梁福鑫. pH-磁双响应Janus笼[J]. 功能高分子学报, 2021, 34(3): 277-283. doi: 10.14133/j.cnki.1008-9357.20200731001
引用本文: 纪旭阳, 张杨, 梁福鑫. pH-磁双响应Janus笼[J]. 功能高分子学报, 2021, 34(3): 277-283. doi: 10.14133/j.cnki.1008-9357.20200731001
JI Xuyang, ZHANG Yang, LIANG Fuxin. pH and Magnetic Responsive Janus Cage[J]. Journal of Functional Polymers, 2021, 34(3): 277-283. doi: 10.14133/j.cnki.1008-9357.20200731001
Citation: JI Xuyang, ZHANG Yang, LIANG Fuxin. pH and Magnetic Responsive Janus Cage[J]. Journal of Functional Polymers, 2021, 34(3): 277-283. doi: 10.14133/j.cnki.1008-9357.20200731001

pH-磁双响应Janus笼

doi: 10.14133/j.cnki.1008-9357.20200731001
基金项目: 石油石化污染物控制与处理国家重点实验室自主课题(RISEAW2019003);国家重点研发计划(2016YFC070090306);国家自然科学基金(51622308,51673119)
详细信息
    作者简介:

    纪旭阳(1985—),男,博士,主要研究方向为高分子复合材料。E-mail:jixuyang@iccas.ac.cn

    通讯作者:

    梁福鑫,E-mail:liangfuxin@tsinghua.edu.cn

  • 中图分类号: O63

pH and Magnetic Responsive Janus Cage

  • 摘要: 通过对介孔二氧化硅壳层的外侧和内侧选择性接枝亲水聚合物聚乙二醇-叶酸(PEG-FA)和pH响应性聚合物聚甲基丙烯酸二乙氨基酯(PDEAEMA),制备了pH响应性Janus笼。研究了Janus笼的化学组成及微观结构。结果显示:Janus笼具有明确的化学分区,且内核具有顺磁性,可在磁场作用下对其进行操控;当pH>7.2时,Janus笼内部亲油,可实现对油溶性物质的选择性装载;当pH<7.2时,Janus笼内部亲油,可实现油溶性物质释放。以盐酸阿霉素为模型,考察了其作为pH响应性药物载体对油溶性药物的装载及可控释放,载药后的Janus笼在模拟肿瘤pH环境下,可实现响应性的药物释放。

     

  • 图  1  pH-磁双响应Janus笼的合成:(a)外侧修饰羧基的Fe3O4@mSiO2颗粒;(b)外侧由PEG-FA基团修饰的“蛋黄-蛋壳”结构磁性Janus笼;(c)pH-磁双响应Janus笼

    Figure  1.  Preparation of pH and magnetic responsive Janus cages: (a)Fe3O4@mSiO2 particles with carboxyl modified on external surface; (b)Magnetic “yolk-shell” Janus cages with PEG-FA groups modified on external surface; (c)pH and magnetic responsive Janus cages

    图  2  Fe3O4纳米颗粒的(a)SEM和(b)TEM照片;Fe3O4@mSiO2颗粒的(c)SEM和(d)TEM照片

    Figure  2.  (a)SEM and (b) TEM images of Fe3O4 NPs; (c)SEM and (d)TEM images of Fe3O4@mSiO2 particles

    图  3  样品的XRD光谱

    Figure  3.  XRD patterns of samples

    图  4  样品的FT-IR谱图

    Figure  4.  FT-IR spectra of samples

    图  5  样品的UV-Vis曲线

    Figure  5.  UV-Vis curves of samples

    图  6  样品的TGA曲线

    Figure  6.  TGA curves of samples

    图  7  Janus笼的 (a)SEM和 (b, c)TEM照片

    Figure  7.  (a) SEM and (b, c)TEM images of the Janus cages

    图  8  接枝PDEAEMA(a)前、(b)后的Janus 笼的TEM照片

    Figure  8.  TEM images of Janus cages (a)before and (b) after grafting the PDEAEMA

    图  9  Janus笼的pH响应性:(a1)正己烷(上层)-水(下层)两相体系,正己烷中加入显色剂dil-C18;(a2)在pH=8条件下加入20 mg Janus笼;(a3)正己烷因被Janus笼富集而从水相中分离;(a4)在pH=5条件下,Janus笼将正己烷释放;(b)在pH=8条件下,装载了正己烷的Janus笼和(c)在pH=5条件下,Janus笼将正己烷释放后的激光共聚焦显微镜照片

    Figure  9.  pH responsive of the Janus cage:(a1)Immiscible mixture of hexane (top) and water(bottom), dil-C18 was added in hexane as the chromogenic agent;(a2)after adding the Janus cage in the mixture under stirring at pH 8; (a3)magnetic collection of the Janus cage at pH 8; (a4)triggered release of hexane from the Janus cage at pH 5; fluorescence microscopy images of (b) the Janus cage filled with hexane at pH 8 and (c) after release of oil at pH 5

    图  10  装载DOX的Janus笼的药物释放曲线

    Figure  10.  Drug release profiles of DOX-loaded Janus cages

    表  1  不同DOX含量下Janus笼的载药率

    Table  1.   Drug loading capacity of Janus cages at different content of DOX

    mDOX /mCagesE/%
    0.23.2
    0.48.2
    0.616.1
    1.025.7
    10.026.5
    下载: 导出CSV
  • [1] de GENNES P G. Soft matter [J]. Rev Mod Phys,1992,64:645-648. doi: 10.1103/RevModPhys.64.645
    [2] WALTHER A, MÜLLER A H E. Janus particles: Synthesis, self-assembly, physical properties, and applications [J]. Chem Rev,2013,113:5194-5261. doi: 10.1021/cr300089t
    [3] LIANG F X, ZHANG C L, YANG Z Z. Rational design and synthesis of Janus composites [J]. Adv Mater,2014,26:6944-6949. doi: 10.1002/adma.201305415
    [4] 刘子强, 张国颖. 基于不对称星形聚合物制备Janus杂化金纳米粒子 [J]. 功能高分子学报,2020,33(4):342-349.

    LIU Z Q, ZHANG G Y. Preparation of Janus hybrid gold nanoparticles based on asymmetric star polymers [J]. Journal of Functional Polymers,2020,33(4):342-349.
    [5] 任宝娜, 皮浩弘, 谷英姝, 等. Janus膜的制备及其应用研究进展 [J]. 材料工程,2020(7):72-80.

    REN B N, PI H H, GU Y S, et al. Research progress in preparation and application of Janus membranes [J]. Journal of materials Engineering,2020(7):72-80.
    [6] LIANG F X, LIU J G, Z YANG Z Z, et al. Janus hollow spheres by emulsion interfacial self-assembled sol-gel process [J]. Chem Commun,2011,47:1231-1233. doi: 10.1039/C0CC03599H
    [7] CHEN Y, YANG H L, YANG Z Z, et al. Janus cages of bilayered polymer-inorganic composites [J]. Macromolecules,2013,46:4126-4130. doi: 10.1021/ma4006236
    [8] ZHAO Z G, ZHU F Y, LIANG F X, et al. pH-Responsive polymeric Janus containers for controlled drug delivery [J]. Polym Chem,2015,6:4144-4153. doi: 10.1039/C5PY00267B
    [9] 郭曼曼, 汪怡, 李青松. 叶酸修饰长春新碱介孔二氧化硅脂质纳米粒的制备及体外释药研究 [J]. 中国药师,2020,8:1544-1549. doi: 10.3969/j.issn.1008-049X.2020.08.014

    GUO M M, WANG Y, LI Q S. Preparation and in vitro release of vincristine-loaded phospholipid-capped mesoporous silica nanoparticles modified with folic acid as targeting drug delivery system [J]. China Pharmacist,2020,8:1544-1549. doi: 10.3969/j.issn.1008-049X.2020.08.014
    [10] 李程, 律涛, 刘彦. 靶向纳米材料在药物传递过程中的应用 [J]. 沈阳药科大学学报,2020,37(8):756-763.

    LI C, LYU T, LIU Y. Application of targeted nanomaterials in drug delivery system [J]. Journal of Shenyang Pharmaceutical University,2020,37(8):756-763.
    [11] 韩克, 张国颖. 双重响应两亲性聚前药的合成及其在药物控释方面的应用 [J]. 功能高分子学报,2018,31(2):98-107.

    HAN K, ZHANG G Y. Synthesis of dual responsive amphiphilic polyprodrug and its application in controlled drug release [J]. Journal of Functional Polymers,2018,31(2):98-107.
    [12] 赵鑫, 曹明, 冯晓双, 等. 阿霉素化学键接聚合物纳米颗粒的合成及pH敏感释放 [J]. 功能高分子学报,2015,28(3):281-287.

    ZHAO X, CAO M, FENG X S, et al. Synthesis and pH-sensitive drug release of dox conjugated polymer nanoparticles [J]. Journal of Functional Polymers,2015,28(3):281-287.
    [13] DENG Y, QI D, DENG C, et al. Superparamagnetic high-magnetization microspheres with an Fe3O4@SiO2 core and perpendicularly aligned mesoporous SiO2 shell for removal of microcystins. [J]. J Am Chem Soc,2008,130:28-29. doi: 10.1021/ja0777584
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出版历程
  • 收稿日期:  2020-07-31
  • 刊出日期:  2021-06-01

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