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    兼具MRI显影增强及pH敏感释药性能的载药Fe3O4纳米颗粒

    Fe3O4 Drug Loading Nanoparticles with MRI Enhancement and pH-Sensitive Drug Release Dual Capability

      摘要
    • 摘要: 以聚丙烯酸(PAA)修饰的超顺磁性Fe3O4纳米颗粒(MNPs-PAA)为基础,利用pH敏感的腙键将抗肿瘤药物阿霉素(DOX)与磁性颗粒表面的PAA链偶联,制备了载药Fe3O4磁性纳米颗粒(MNPs-DOX)。通过透射电镜、X射线衍射、紫外、红外、热失重以及体外磁共振显影(MRI)等手段对MNPs-DOX的形貌、结构、MRI及载释药效果进行了表征。结果证实,MNPs-DOX具有超顺磁性,在MRI中具备良好的横向弛豫(T2)显影增强效果。此外,其DOX负载率达15%(质量分数),且在pH=5.0的酸性环境中药物释放量明显高于pH=7.4的中性环境,具有对环境pH的敏感性。

       

      Abstract: Monodispersed magnetic Fe3O4 nanoparticles(MNPs) capped with polyacrylic acid (MNPs-PAA) were synthesized.On this basis,anticancer drug doxorubicin was loaded onto the PAA chain of magnetic nanoparticles (MNPs-DOX) surface by a pH-sensitive hydrazone bond.The morphology,structure,Magnetic Resonance Imaging (MRI) enhancement and drug release properties of MNPs-DOX were characterized by Transmission Electron Microscope (TEM),X-Ray Diffractometer (XRD),Fourier Transform Infrared spectrometer (FT-IR),Thermal Gravimetric (TG) analyzer,UV-Visible spectrophotometer (UV-Vis) and in vitro MRI.MNPs-DOX exhibited great MRI T2-weighted enhancement capability.The drug-loading capacity of MNPs-DOX was 15% (mass fraction).In vitro experiment demonstrated that the release of DOX was pH-sensitive,and was accelerated at acid environment (pH=5.0) compared with neutral environment (pH=7.4).

       

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