Abstract: Poly(vinyl chloride-co-vinyl acetate) (PVCAc) / thermoplastic polyether polyurethane (TPU) blend films (PUV) were prepared via solution casting. The morphology and miscibility of PUV films were studied by FT-IR and DSC. Results show that PVCAc is more miscible with TPU than poly(vinyl chloride). Accelerated oxidation test was carried out by immersing the blend films in H2O2-CoCl2 solution for 25 d. The oxidative stability of PUV films is significantly enhanced in comparison to that of TPU and TPU/PVC blend films (PUC).Furthermore, the mechanical properties of PUV films are higher than those of PUC films.