可生物降解的pH敏感水凝胶的合成及其溶胀性能研究

Synthesis and Swelling Properties of Biodegradable pH Sensitive PVA-Gelatin Hydrogels

摘要: 采用明胶和聚乙烯醇为原料，制备了戊二醛交联、明胶／聚乙烯醇配比不同的水凝胶，并用FTIR和SEM对产物进行了表征。研究了凝胶的溶胀动力学，结果表明，原料配比对各种凝胶的溶胀速率影响不大，而对平衡溶胀比与原料配比有关，室温下凝胶的平衡溶胀比在300％～500％之间。pH敏感性研究表明，几种凝胶均表现出明显的pH响应性，当溶胀介质的pH值在明胶等电点附近时，水凝胶的溶胀比达到最小值，凝胶的溶胀-消溶胀动力学曲线呈“W”形，即该凝胶具有形状记忆功能。

Abstract: A polymer network composed of polyvinyl acohal (PVA) and gelatin hydrogels were prepared and characterized by Fouier transform infrared spectrophotometer (FTIR) and scanning electron microscopy (SEM). The effects of pH various on swelling hydrogels were i