低热-高压法制备PLGA多孔支架及其体外降解研究

Scaffolds with High Porosity for Tissue Engineering Fabricated by Low Heat-High Pressure and their Degradation in Vitro

摘要: 采用低热-高压法制备了聚(dl-丙交酯／乙交酯)75／25(PLGA75／25)组织工程多孔支架。该方法避免了使用有机溶剂，支架的孔隙率在90％以上，孔径大小分布均匀。多孔支架经过酒精处理后，支架表面产生许多微小的凹陷；用藻酸钙改性处理后，支架形态保持良好。两种处理都使支架的压缩强度有所增大，亲水性增强。虽然孔隙率高的支架降解速率稍慢，但其体外降解规律基本一致：特性粘数争力学强度衰减快，而质量损失较慢，降解6周后，支架的质量损失仅为3％左右；体外降解3周后，支架的形态保持良好，可望在细胞移植争组织修复的早期发挥支撑作用。

Abstract: Poly(dl -lactide- co -glycolide)75/25(PLGA75/25) porous scaffolds for tissue engineering were fabricated by a novel technique of the low heat-high pressure without using organic solvents. The porosity of the scaffolds was up to 90%. Scanning electron micr