甲基丙烯酸在生物相容性微球CPVA表面的引发接枝聚合

Graft Polymerization of Methacrylic Acid on CPVA Microspheres with Biocompatibility

摘要: 交联聚乙烯醇(CPVA)微球表面含有大量的羟基，具有良好的生物相容性。在水溶液体系中利用这些羟基，与铈盐构成氧化还原引发体系，实施了甲基丙烯酸(MAA)的表面引发接枝聚合，制备了接枝微球CPVA-g-PMAA，考察了主要因素对接枝聚合的影响。采用红外光谱(FT-IR)及扫描电子显微镜(SEM)对接枝微球进行了表征。结果表明，羟基铈盐氧化还原引发体系可有效地引发MAA在CPVA微球的表面接枝聚合，当铈盐浓度为4.9×10-3 mol/L、硫酸浓度为0.17 mol/L、反应温度为45 °C、单体浓度为0.54 mol/L时，每100 g接枝微球CPVA-g-PMAA可接枝PMAA 30 g。

Abstract: Crosslinked polyvinyl alcohol (CPVA) microspheres were a class of polymer microspheres with biocompatibility. A redox initiation system was constructed with a great deal of hydroxyl group on CPVA microspheres and cerium ammonium sulfate. The surfaceinitiated graft polymerization of methacrylic acid (MAA) was performed in an aqueous solution, making