沉降法制备新型聚氨酯血液相容性材料

Preparation of New Blood Compatible Polyurethane Materials with Sedimentation

摘要: 采用一种新型聚氨酯纳米微球（PUI-NPs）修饰聚氨酯（PU）薄膜，利用沉降法制备出具有良好血液相容性的聚氨酯/聚氨酯纳米微球(PU/PUI-NPs)。以扫描电镜、红外光谱、X射线光电子能谱对PU/PUI-NPs膜表面结构进行表征。以血小板黏附、复钙、溶血和蛋白吸附实验对PU/PUI-NPs膜的血液相容性进行了表征。结果表明:PUI-NPs已被成功引入PU膜表面，PU/PUI-NPs膜的血液相容性比PU有显著的提高,相比于PU,PU/PUI-NPs膜的细胞毒性更低。

Abstract: A kind of novel polyurethane ionomer nanoparticles (PUI-NPs) were used to modify polyurethane (PU) films. An excellent blood compatible polyurethane/polyurethane ionomer nanoparticles composite film (PU/PUI-NPs film) was prepared with sedimentation. The structure of the PU/PUI-NPs film was characterized with SEM, ATR-FTIR and XPS. Platelet adhesion, recalification time, hemolysis and protein adsorption measurement were used to assess the blood compatibility of PU/PUI-NPs film. Results showed that PUI-NPs was introduced into the PU surface successfully. The blood compatibility of PU/PUI-NPs film was improved remarkably, compared with that of PU. PU/PUI-NPs film had lower cytotoxicity than PU.