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    周敏1，2, 彭政2, 廖双泉1, 李思东3, 李普旺2. 叶酸修饰碳纳米管的合成及其负载伊立替康的释放[J]. 功能高分子学报, 2012, 25(4).
    引用本文: 周敏1，2, 彭政2, 廖双泉1, 李思东3, 李普旺2. 叶酸修饰碳纳米管的合成及其负载伊立替康的释放[J]. 功能高分子学报, 2012, 25(4).
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    ZHOU Min1,2, PENG Zheng2, LIAO Shuang quan1, LI Si dong3, LI Pu wang2. Synthesis of Folate Decorated Carbon Nanotubes and Its Irinotecan Release[J]. Journal of Functional Polymers, 2012, 25(4).
    Citation: ZHOU Min1,2, PENG Zheng2, LIAO Shuang quan1, LI Si dong3, LI Pu wang2. Synthesis of Folate Decorated Carbon Nanotubes and Its Irinotecan Release[J]. Journal of Functional Polymers, 2012, 25(4).
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    叶酸修饰碳纳米管的合成及其负载伊立替康的释放

    Synthesis of Folate Decorated Carbon Nanotubes and Its Irinotecan Release

      摘要
    • 摘要: 以叶酸改性壳聚糖修饰的碳纳米管为药物载体，选用治疗结肠癌的抗癌药物伊立替康为模型药物，通过非共价包覆的方式制备具有靶向功能的碳纳米管基药物载体材料。采用FT-IR、UV和TGA等对各阶段产物进行表征，考察了纳米载体的载药率和药物体外释放性能。结果表明，模型药物成功加载到了功能化的碳纳米管上，其载药量达63.6%，包封率为85.92%。体外释放实验显示靶向功能化碳纳米管对伊立替康具有缓释作用，药物在37 ℃，pH=7.4的PBS缓冲溶液中能持续释放70 h以上。

       

      Abstract: Multi walled carbon nanotubes (MWCNTs) functionalized by folate (FA) conjugated chitosan (CS) were used as drug carrier. Irinotecan, as a model of anticancer drug, was non covalently encapsulated into (or onto) the functionalized carbon nanotubes. The obtained FA-CS MWCNTs nano materials were characterized with infrared spectra, UV-Vis spectroscopy and thermogravimetric ana lysis, and the drug loading efficiency and in vitro drug release profile was also studied. Results showed that the irinotecan was successfully loaded into functionalized carbon nanotubes, and the drug loading efficiency and encapsulated efficiency were 63.6% and 85.92%, respectively. The mass fraction of folate modified chitosan, carbon nanotubes and irinotecan in FA CS MWCNTs irinotecan was 18.6%, 44.3% and 38.9%, respectively. The release of irinotecan from carbon nanotubes at pH=7.4 showed a slow and sustained release over 70 h.

       

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