高分子药物-可乐定阴离子丙烯酸树脂盐的研制及释药性能探索
Preparation and Propertieds of Clonidine-anionic Resin Polymeric Drug
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摘要: 研制了高分子药物-可乐定阴离子丙烯酸树脂盐并在模拟胃和小肠pH的缓冲液中进行了高分子药物的溶解释放试验。结果表明其中某些试样能够在微碱性的缓冲液中缓慢溶解释放,可望达到减少用药量。降低副作用和延长药效的目的。Abstract: Five anionic acrylic resins were synthesized by solution Polymerization using methyl methacrylate, methacrylic acid and acrylic acid. The Polymeric drugs of clonidine-anionic acrylic resin have been prepared. The dissolution release test of polymeric drug