聚氨酯生物吸收材料及其作为缓释药物载体的研究
The Synthesis of Bioabsorbable Polyurethane and its Study as a Drug Delivery System Carrier
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摘要: 合成了一系列新的紫外光固化生物吸收性聚氨酯水凝胶网络,测定了材料的含水率及水解性能,并以之为载体,研究了对异烟肼的药物缓释性能。结果表明,该水凝胶的含水率及降解速率与其结构有关,该水凝胶对异烟肼具有缓释作用,释放行为受扩散控制并符合Higuchi方程,表观扩散系数与水凝胶的含水率有关。Abstract: A series of bioabsorbable polyurethane network hydrogels were systhesized.The controlled release properties of the hydrogel as a carrier for isonia-zidum had been investigated. Results indicated that the water content and degradation kinetic