Abstract: A series of poly(butylene succinate-co-1,4-cyclohexane dimethanol succinate) random copolyesters were synthesized by melt polycodensation. The structure and physical properties of the aliphatic polyesters were characterized by hydrogen nuclear magnetic resonance spectrum (1H-NMR), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), X ray diffraction (XRD) and lipase enzymatic degradation test. Results show that the synthetic copolyesters are the expected products, the crystal structure of copolyesters has been changed and the cocrystallization behavior has appeared. The melting point of the product decreases from 113.7 ℃ to 64.6 ℃, and then increases to 114.2 ℃. Moreover, the glass transition temperature increases monotonously from -33.8 ℃ to 5.4 ℃ along with the increasing of 1,4-cyclohexane dimethanol succinate (CHDM) component. With the increasing of 1,4-cyclohexane dimethanol component, the copolyesters have better thermal stability. The lipase enzymatic degradation tests indicate that the copolyesters P51 and P31 have better degradability, and P51 has the fastest degradation.