Abstract: Eye diseases have emerged as a prevalent health concern in modern society. Drug-loaded contact lenses, compared to traditional delivery approaches, possess the potential to enhance drug bioavailability and reduce the incidence of adverse reactions. They are expected to become a safe, effective, and convenient therapeutic method for patients. Using methyl methacrylate β-hydroxyethyl methacrylate (HEMA) as the main monomer, methyl methacrylate-modified hyaluronic acid ester (MAHA), α-methyl methacrylate (MAA), acrylamide (AM), or N-vinyl pyrrolidone (NVP) as functional monomers, and tea polyphenol epigallocatechin gallate ester (EGCG) as the template molecule, a sequence of molecularly imprinted hydrogel contact lenses were prepared via the molding method. The composition, surface morphology, water contact angle, equilibrium water content, light transmittance, and loading and delivery of EGCG were systematically characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible spectrophotometry (UV-Vis), and contact angle measurements. Results indicate that the incorporation of functional monomers significantly enhance the water content and surface hydrophilicity of pHEMA contact lenses. Compared to non-molecularly imprinted lenses, the utilization of molecular imprinting technology increase the loading capacity of EGCG in the contact lenses and reduce its release rate. Moreover, UV testing and 1,1-diphenyl-2-picrylhydrazyl (DPPH) clearance experiments substantiate that the EGCG-loaded lenses display ultraviolet protection and free radical scavenging. These molecularly imprinted hydrogel contact lenses have the promising potential and practical applications of such lenses within the field of ophthalmic health and therapeutics.