Abstract:
In order to develop a wound dressing loaded with pomegranate peel extract (PPE), the hydrogel was prepared by cyclic freeze-thaw method using polyvinyl alcohol (PVA) and sodium carboxymethyl cellulose (Na-CMC) as raw materials, glycerol (GL) aqueous solution was used as the solvent. Subsequently, the chemical structure of hydrogels was analyzed by FT-IR. In addition, the transmittance, anti-drying, swelling, tensile properties,
in vitro drug release, anti-oxidation and antibacterial properties of hydrogels were also studied. Results showed that the prepared hydrogels had good drying resistance and could remain intact at room temperature for 72 h. The addition of PPE reduced the light transmittance of the hydrogel, improved the swelling and tensile property of the hydrogel, and made the hydrogel have good antibacterial and antioxidant properties. The cumulative release of PPE in the hydrogel was (67.47 ± 3.75)%, which showed good antibacterial activity against
Staphylococcus aureus and
Escherichia coli. The inhibition zones were (18.78 ± 0.26) mm and (15.11 ± 0.23) mm, respectively. The highest scavenging rate to 1,1-diphenyl-2-picrylhydrazyl (DPPH) was (93.65 ± 2.27)%. Therefore, the hydrogel loaded with PPE prepared in this study has the potential as a wound dressing.