Abstract: Ionic conductive hydrogels exhibit good electrical conductivity, excellent tensile properties and high biocompatibility, which is of great significance in the fields of flexible electronic equipment, human-machine interface and health monitoring. By using acrylamide (AAm) monomer and methyl acryloxyethyl trimethylammonium chloride (DMC) cationic monomer as copolymers and adding a certain amount of anionic polyelectrolyte sodium polyacrylate (PAAS), ionic conductive hydrogels with hybrid crosslinking network(P(AAm-DMC)-PAAS) are prepared. The mechanical properties of hydrogel can be effectively regulated by changing the density of chemical crosslinking and ionic crosslinking in hydrogel networks. The experimental results show that the maximum stress of the hydrogel can reach (88.4±4.7) kPa and the maximum strain is (1030.8±71.7)%. Because PAAS and DMC can ionize abundant free ions, P(AAm-DMC)-PAAS hydrogel can maintain high ionic conductivity and rapid response to strain without additional conductive filler, with conductivity up to 0.684 S/m and sensitivity factor GF about 2.409(0—70% strain range). The hydrogel can be used as a wearable strain sensor to monitor arm bending, finger bending, knee bending and other human movements through changes in relative resistance. The hydrogel can also be assembled into epidermal electrodes, which can accurately detect human physiological signals. Therefore, the P(AAm-DMC)-PAAS has the potential as a multifunctional sensor, which is expected to broaden its application in flexible electronic equipment, intelligent medical and other fields.