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    薛苏桐, 王先流, 易兵成, 等. 氧化石墨烯改性形状记忆纤维的片层尺寸相关性[J]. 功能高分子学报,2022,35(2):146-154. doi: 10.14133/j.cnki.1008-9357.20210411001
    引用本文: 薛苏桐, 王先流, 易兵成, 等. 氧化石墨烯改性形状记忆纤维的片层尺寸相关性[J]. 功能高分子学报,2022,35(2):146-154. doi: 10.14133/j.cnki.1008-9357.20210411001
    XUE Sutong, WANG Xianliu, YI Bingcheng, GUO Xuran, TANG Han, SHEN Yanbing, ZHANG Yanzhong. Lateral Size Dependence of Graphene Oxide in Modifying Shape Memory Fibers[J]. Journal of Functional Polymers, 2022, 35(2): 146-154. doi: 10.14133/j.cnki.1008-9357.20210411001
    Citation: XUE Sutong, WANG Xianliu, YI Bingcheng, GUO Xuran, TANG Han, SHEN Yanbing, ZHANG Yanzhong. Lateral Size Dependence of Graphene Oxide in Modifying Shape Memory Fibers[J]. Journal of Functional Polymers, 2022, 35(2): 146-154. doi: 10.14133/j.cnki.1008-9357.20210411001

    氧化石墨烯改性形状记忆纤维的片层尺寸相关性

    Lateral Size Dependence of Graphene Oxide in Modifying Shape Memory Fibers

    • 摘要: 将不同片层大小的氧化石墨烯(GO)通过电纺丝方法掺杂到左旋聚乳酸/聚(3-羟基丁酸酯-co-3-羟基戊酸酯)(PLLA/PHBV)形状记忆复合纤维中形成GO@PLLA/PHBV复合纤维膜。通过拉曼光谱(Raman)、场发射扫描电镜(FESEM)、透射电镜(TEM)、X射线衍射(XRD)及差示扫描量热(DSC)等对复合纤维膜的形貌、结构和热性能进行了表征。采用动态热机械分析(DMA)、形状回复应力测试及光热升温实验分析了复合纤维膜的形状记忆性能。通过细胞增殖和成骨分化实验检测GO片层大小对复合纤维膜的成骨诱导作用。结果表明,小尺寸GO(sGO)的掺入对PLLA/PHBV复合纤维膜的力学增强及形状回复效果最为显著,可使拉伸杨氏模量提高约124%,形状回复应力增大约29%,形状回复率增大约47%,热响应速率提高约30倍;但在成骨诱导方面,掺入大尺寸GO(lGO)的PLLA/PHBV复合纤维膜则具有最优的成骨诱导性能,使骨髓间充质干细胞(BMSCs)中的碱性磷酸酶(ALP)分泌量提高了92%,钙沉积提高了133%。

       

      Abstract: Graphene oxide (GO) with different lateral sizes was doped into the shape memory capable fibrous membranes of poly(L-lactic acid)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PLLA/PHBV) composite via electrospinning. A series of characterizing techniques such as Raman spectroscopy (Raman), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and differential scanning calorimetry (DSC) were employed to characterize the structure and thermal properties of the fibrous composite membranes. Thereafter, shape memory properties were determined by dynamic mechanical analysis (DMA), shape recovery stress, and photothermal effect test. Finally, the effect of GO lateral sizes on the osteodifferentiation capacity of bone mesenchymal stem cells (BMSCs) cultured on the fibrous composite membranes was examined by conducting cell proliferation and osteodifferentiation relevant assays. It was found that incorporation of small-sized GO (sGO) into the fibrous composite membranes gave rise to the most significant reinforcing effects on the mechanical strengthening and shape recovery capability of the fibrous PLLA/PHBV membranes, with the tensile Young's modulus increased by about 124%, the shape recovery stress increased by about 29%, the shape recovery rate increased by about 47%, and the thermal responsive rate increased by about 30 fold. In terms of osteogenic performance, the fibrous PLLA/PHBV membranes doped with large-sized GO (lGO) demonstrated the best osteogenic induction capacity in BMSCs, with the secreted alkaline phosphatase (ALP) increased by 92% and the calcium deposits by 133%.

       

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