Abstract: Reactive oxygen species (ROS) is an important class of intermediate products during the metabolism process, which plays a key role to maintain the normal physiological activities in human body. The overexpression of ROS can lead to a series of inflammatory responses, resulting in a range of acute and chronic human inflammatory diseases. In recent years, the antioxidant materials have become a hot spot applied to scavenge ROS for treating inflammatory diseases. Meanwhile, the hydrogel is regarded as one of the promising materials due to its unique biomimic properties and multiple biofunctions. In this review, we summarize the recent advances in antioxidant hydrogels, including the antioxidant mechanism, the fabrication strategies, and related application in biomedical area. The further perspective in this field is also discussed.