Abstract: The proanthocyanidin (PC)-enhanced polyethylene glycol (PEG)-lysozyme (LZM) hydrogel (PEG-LZM-PC) was prepared based on PEG-LZM hydrogel by post-soaking with PC. The morphology, structure and mechanical properties of PEG-LZM-PC were characterized by scanning electron microscope (SEM), Fourier-transformed infrared (FT-IR) spectroscopy and universal testing instruments. Antibacterial ability of PEG-ZEM-PC was evaluated by plate coating method. The effect of PEG-LZM-PC on the expression of inflammatory factors in immune cells was evaluated by quantitative reverse transcription PCR (RT-qPCR). The results showed that the strength and toughness of PEG-LZM-PC were significantly improved compared with PEG-LZM; the antibacterial performance of PEG-LZM-PC in vivo and in vitro was pretty good; and the inflammatory response caused by lipopolysaccharide (LPS) stimulation was inhibited by PEG-LZM-PC, which is expected to promote wound healing.