Abstract: Poly(propylene fumarate) (PPF) resin was synthesized by two-step method using diethyl fumarate and 1, 2-propylene glycol as reactants. PPF bone cement was prepared by adding initiator, crosslinking agent and accelerator. A series of properties of PPF bone cement including crosslinking curing time, crosslinking exothermic temperature and compressive strength were inspected by temperature measurement, Differential Scanning Calorimetry (DSC) and mechanical strength test. The curing performance of bone cement was investigated using different molecular weights of PPF and different doses of additives, such as crosslinking agent (N-vinylpyrrolidone (NVP)), initiator (benzoyl peroxide (BPO)) and accelerator (N, N-dimethyl p-toluidine (DMT)). Results show that PPF bone cement prepared by adding 0.25 mL NVP, 5 mg BPO, 20 μL DMT to 1 g PPF resin has the best curing property. Compared with commercial poly(methyl methacrylate) (PMMA) cement, PPF bone cement has better mechanical properties and biocompatibility. Moreover, the reaction exothermic during the curing process is relatively low.